Long chain fatty acids and gene expression in inflammation and immunity.
Philip Calder, PhD ,
Nom de la revue: Current Opinion in Clinical Nutrition & Metabolic Care 16(4): 425-433.
Purpose of review. The purpose of this review is to discuss recent studies reporting on the influence of fatty acids on gene expression in relation to inflammation and immune responses. Recent findings. Saturated fatty acids promote, whereas several n-3 fatty acids, in particular eicosapentaenoic and docosahexaenoic acids, some isomers of conjugated linoleic acid, and punicic acid suppress, expression of inflammatory genes. The most common targets of fatty acids are genes encoding cytokines, chemokines, cyclooxygenase, nitric oxide synthase, and matrix metalloproteinases. The anti-inflammatory actions of fatty acids often involve inhibition of activation of nuclear factor- kappaB and activation of peroxisome proliferator-activated receptors alpha and gamma. Common upstream events include actions on Toll-like receptors and via G-protein coupled receptors. Fatty acids can influence expression of genes involved in immune and inflammatory cell development and differentiation. Recent studies using genome-wide analyses demonstrate that dietary fatty acids can alter expression of a large number (many hundreds) of genes in human peripheral blood mononuclear cells. Summary. A wide range of fatty acids alter expression of genes involved in development, differentiation, and function of cells involved in inflammation and immunity.